Endocrine Abstracts

The systemic function of thyroid hormones (TH) is highly dependent on their local action in distinct cell populations. A major target of TH are immune cells, yet knowledge on the effect of TH on immune responses is still incomplete. Within this study we aimed to determine the impact of TH on T cells, key players of immune responses, in more detail. To this end, we analyzed the activation and function of T cells from mice lacking TRα (TRα0/0) or expressing ...

The thyroid hormone (TH) transporters Mct8 (encoded by Slc16a2) and Oatp1c1 (encoded by Slco1c1) are critically involved in mediating TH passage across mouse brain barrier cells. Mct8/Oatp1c1 deficient mice (= DKO mice) exhibit a strongly reduced brain TH content and consequently, an impaired neuronal development and hypomyelination all of which are also seen in patients with MCT8 deficiency (Allan-Herndon-Dudley Syndrome, AHDS). Our recent studies of mouse mutants lacking bot...

Thyroid hormones (TH) reduce liver steatosis. As steatosis is the initial step of alcoholic liver disease (ALD), we hypothesized that TH treatment could ameliorate ALD. Wildtype (WT) mice were treated with either ethanol (EtOH) or liquid control diet for 10 days followed by a single EtOH or maltose binge on day 11. In both groups, diet was supplemented with either T3 or solvent. Serum triglycerides (TG) were increased by EtOH and, surprisingly, further elevated by T3. Liver we...